Tyler Ulland, PhD

tulland@wisc.edu

Department: Pathology and Laboratory Medicine                                                                    

Immunology Focus area: Neuroimmunology of Neurodegenerative Diseases                             

Descriptive Title of Research: Determining the Role of the Innate Immune Response in AD               

Research Description:

Research in the Ulland Lab is focused on gaining a deeper understanding of the mechanisms, including metabolic and transcriptional changes, which govern the innate immune response in neurodegeneration with a focus on Alzheimer’s disease (AD). Our interests fall into 4 distinct areas:

  1. Defining the role of microglial autophagy and TREM2 signaling in AD.
  2. Investigating the role of systemic inflammation on microglia prior to and during AD.
  3. Determining the role of microglia in recruiting and influencing the functionality of neutrophils during AD pathogenesis.
  4. Examining the effect of different carbohydrate sources on the microglia in 5XFAD and non-5XFAD animals with or without the expression of Trem2.

Ultimately the goal of our research is to inform the design of new therapeutic approaches to AD with a particular focus on targeting and modifying the innate immune response during neurodegeneration.

Link to Publications: https://www.ncbi.nlm.nih.gov/pubmed/?term=Ulland+T%5BAuthor%5D

Graduate Program Affiliations: Cellular and Molecular Pathology Graduate Program

Lab Website: https://ulland.pathology.wisc.edu