Tyler Ulland, PhD
Department: Pathology and Laboratory Medicine
Immunology Focus area: Neuroimmunology of Neurodegenerative Diseases
Descriptive Title of Research: Determining the Role of the Innate Immune Response in AD
Research in the Ulland Lab is focused on gaining a deeper understanding of the mechanisms, including metabolic and transcriptional changes, which govern the innate immune response in neurodegeneration with a focus on Alzheimer’s disease (AD). Our interests fall into 4 distinct areas:
- Defining the role of microglial autophagy and TREM2 signaling in AD.
- Investigating the role of systemic inflammation on microglia prior to and during AD.
- Determining the role of microglia in recruiting and influencing the functionality of neutrophils during AD pathogenesis.
- Examining the effect of different carbohydrate sources on the microglia in 5XFAD and non-5XFAD animals with or without the expression of Trem2.
Ultimately the goal of our research is to inform the design of new therapeutic approaches to AD with a particular focus on targeting and modifying the innate immune response during neurodegeneration.
Link to Publications: https://www.ncbi.nlm.nih.gov/pubmed/?term=Ulland+T%5BAuthor%5D
Graduate Program Affiliations: Cellular and Molecular Pathology Graduate Program
Lab Website: https://ulland.pathology.wisc.edu