John Yin, PhD

Department: Chemical & Biological Engineering; Systems Biology, Wisconsin Institute for Discovery

Immunology Focus area: Infectious Disease, Innate and Adaptive Immunity, Systems Immunology

Descriptive Title of Research: Systems biology of virus-host interactions

Research Description: An aim of infection forecasting is to combine measures and models of pathogen-host interactions to predict the course of infections in the presence and absence of any number of therapeutic interventions. Measures entail multi-omic characterization of host innate and adaptive immune responses, as well as microbiome perturbations, in response to infection by pathogenic viruses or bacteria. A particular focus has been on developing single-cell multi-gene reporters of virus-host interactions, to better understand how the heterogeneity of host responses reflect underlying mechanisms. Models entail mechanistic kinetic representations of molecular and cellular processes, up to tissue and adaptive host responses to infection. Specific emphasis has been on linking models of viral gene expression to host innate immune activation and the predicting how downstream infection spread depends on early events. A long-term goal of our research is to develop optimal treatments for precision medicine in the area of infectious disease.

Link to Publications:

https://scholar.google.com/citations?user=3zQqRq8AAAAJ&hl=en

Graduate Program Affiliations:

Chemical and Biological Engineering, Cellular and Molecular Biology Program, Madison Virology Program, Quantitative Biology Initiative

Lab Website:     https://yinlab.discovery.wisc.edu/